What you need

KidneyHD edits the pedal on its own over USB. Install KidneyHD Audio as well if you want USB audio:

KidneyHD alone KidneyHD with KidneyHD Audio
Edit presets, models, footswitches, settings Yes Yes
Play Mac audio through the pedal, record from it No Yes
Edit while audio plays No Yes
Mac volume keys and slider for the pedal No Yes
Serial number, USB firmware, model packs in Settings Yes Yes

Only one app at a time can use the pedal's editing channel. With KidneyHD Audio installed, KidneyHD edits through KidneyHD Audio's service, and the sidebar footer says "via KidneyHD Audio". Without it, the footer says "USB".

The pedal's analog and S/PDIF outputs work without any driver. Firmware updates still need Line 6 Monkey and Line 6's own driver.